The recent publication of CARBAFIN‘s team from Graz University of Technology bridges the gap between an enzyme kinetic model considered for mechanistic research and the application of the model to predict technologically relevant reaction conditions. The paper describes a three-level hybrid modeling approach and how it can be used for systematic optimization of biocatalytic synthesis. The study provides valuable conclusions for the glucosylglycerol production from sucrose at industrial scale.
The article was published in “Biotechnology and Bioengineering” and the underlying experimental data set is also available.
Read more: https://doi.org/10.1002/bit.27878
Sigg A, Klimacek M, Nidetzky B: Three-level hybrid modeling for systematic optimization of biocatalytic synthesis: a-glucosyl glycerol production by enzymatic trans-glycosylation from sucrose. 2021, Biotechnology and Bioengineering, 118 (10), p4028 – 4040
Picture: Cover page of Biotechnology and Bioengineering